中文名称 β4整合素结合蛋白抗体 古朵生物

　　英文名称 eIF6

　　别 名 b(2)gcn; B(2)GCN homolog; B4 integrin interactor; Binding protein of beta-4 integrin; CAB; eIF-6; EIF3A; EIF6; Eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; IF6_HUMAN; ITGB4BP; OK/SW-cl.27; p27 beta 4 integrin binding protein; p27(BBP); p27BBP; RP4-614O4.1.

　　研究领域 肿瘤 免疫学 信号转导 转录调节因子

　　抗体来源 Rabbit

　　克隆类型 Polyclonal

　　交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,

　　产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 β4整合素结合蛋白抗体(石蜡切片需做抗原修复)

　　not yet tested in other applications.

　　optimal dilutions/concentrations should be determined by the end user.

　　分 子 量 27kDa

　　细胞定位 细胞核 细胞浆

　　性 状 Lyophilized or Liquid

　　浓 度 1mg/1ml

　　免 疫 原 KLH conjugated synthetic peptide derived from human ITGB4BP C-terminus

　　亚 型 IgG

　　纯化方法 affinity purified by Protein A

　　储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

　　保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

　　β4整合素结合蛋白抗体产品介绍 background:

　　Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by Intergrin beta 4 binding protein binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.

　　Function:

　　Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.

　　Subunit:

　　Belongs to the eIF-6 family.

　　Subcellular Location:

　　Cytoplasm. Nucleus. nucleolus. Shuttles between cytoplasm and nucleus/nucleolus.

　　Tissue Specificity:

　　Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).

　　Post-translational modifications:

　　Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.

　　古朵生物：β4整合素结合蛋白抗体应用方法 上海古朵生物科技有限公司成立于上海浦东新区。是一家专门从事生物技术相关产品，励志研发和销售的综合性生物公司，产品远销多个国家和地区，我们将一如既往地秉承“一切为了满足客户的需求"的经营宗旨;牢固树立“以客户需求为准则、以市场需求为导向，不断开发高质量的新产品，提供客户满意的综合服务质量"的方针。