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产品名称:DULLARD蛋白抗体
别名:Dullard homolog; HSA 011916; NET 56 antibodySerine threonine protein phosphatase dullard; CNEP1_HUMAN.
浓度:1mg/1ml
规格:0.2ml/200μg
抗体来源:Rabbit
克隆类型:polyclonal
交叉反应:Human, Mouse, Rat, Dog, Cow, Horse
产品类型:DULLARD蛋白抗体一抗
研究领域:神经生物学 信号转导 激酶和磷酸酶 表观遗传学
蛋白分子量:predicted molecular weight: 28kDa
性状:Lyophilized or Liquid
免疫原:KLH conjugated synthetic peptide derived from human DULLARD
亚型:IgG
纯化方法:affinity purified by Protein A
储存液:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍:In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. Dullard, also known as NET56, is a 244 amino acid single-pass membrane protein that localizes to both the nucleus and the endoplasmic reticulum and contains one FCP1 homology domain. Functioning as a serine/threonine phosphatase, Dullard catalyses the dephosphorylation of target proteins and is thought to be required for proper nuclear membrane morphology. Human Dullard shares 92% sequence identity with its zebrafish counterpart, suggesting a conserved role between species.
Function : DULLARD is a serine/threonine phosphatase which may be required for proper nuclear membrane morphology. It is involved in LPIN1 dephosphorylation and may antagonize BMP signaling.
Subunit : Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.
Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Nuclear membrane; Single-pass membrane protein.
Tissue Specificity : Muscle specific with lower expression in other metabolic tissues.
Similarity : Belongs to the dullard family.
Contains 1 FCP1 homology domain.
Database links : UniProtKB/Swiss-Prot: O95476.2 |